Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model

Latrepirdine (Dimebon™) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to moderate Alzheimer’s disease, with a dramatically positive outcome in a Russian clinical trial that was unconfirmed in a replication trial in the United States. We sought...

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Hlavní autoři: Steele, John W., Lachenmayer, M. Lenard, Ju, Shulin, Stock, Aryeh, Liken, Jessica, Kim, Soong Ho, Delgado, Luz M., Alfaro, Iván E, Bernales, Sebastian, Verdile, Giuseppe, Bharadwaj, Prashant, Gupta, Veer, Barr, Renae, Friss, Amy, Dolios, Georgia, Wang, Rong, Ringe, Dagmar, Fraser, Paul, Westaway, David, St George-Hyslop, Peter H., Szabo, Paul, Relkin, Norman R., Buxbaum, Joseph D., Glabe, Charles G., Protter, Andrew A., Martins, Ralph N., Ehrlich, Michelle E., Petsko, Gregory A., Yue, Zhenyu, Gandy, Sam
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625697/
https://ncbi.nlm.nih.gov/pubmed/22850627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2012.106
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