Latrepirdine (Dimebon(™)) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast

Latrepirdine (Dimebon(™)), an anti-histamine, has shown some benefits in trials of neurodegenerative diseases characterized by accumulation of aggregated or misfolded protein such as Alzheimer’s disease (AD) and has been shown to promote the removal of α-synuclein protein aggregates in vivo. An impo...

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Main Authors: Bharadwaj, Prashant R., Verdile, Giuseppe, Barr, Renae K., Gupta, Veer, Steele, John W., Lachenmayer, M. Lenard, Yue, Zhenyu, Ehrlich, Michelle E., Petsko, Gregory, Ju, Shulin, Ringe, Dagmar, Sankovich, Sonia E., Caine, Joanne M., Macreadie, Ian G., Gandy, Sam, Martins, Ralph N.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529125/
https://ncbi.nlm.nih.gov/pubmed/22903131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-120178
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