Latrepirdine (Dimebon(™)) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast

Latrepirdine (Dimebon(™)), an anti-histamine, has shown some benefits in trials of neurodegenerative diseases characterized by accumulation of aggregated or misfolded protein such as Alzheimer’s disease (AD) and has been shown to promote the removal of α-synuclein protein aggregates in vivo. An impo...

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Hlavní autoři: Bharadwaj, Prashant R., Verdile, Giuseppe, Barr, Renae K., Gupta, Veer, Steele, John W., Lachenmayer, M. Lenard, Yue, Zhenyu, Ehrlich, Michelle E., Petsko, Gregory, Ju, Shulin, Ringe, Dagmar, Sankovich, Sonia E., Caine, Joanne M., Macreadie, Ian G., Gandy, Sam, Martins, Ralph N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529125/
https://ncbi.nlm.nih.gov/pubmed/22903131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2012-120178
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