Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

BACKGROUND: Recent reports suggest that latrepirdine (Dimebon™, dimebolin), a retired Russian antihistamine, improves cognitive function in aged rodents and in patients with mild to moderate Alzheimer's disease (AD). However, the mechanism(s) underlying this benefit remain elusive. AD is charac...

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Detalhes bibliográficos
Main Authors: Steele, John W, Kim, Soong H, Cirrito, John R, Verges, Deborah K, Restivo, Jessica L, Westaway, David, Fraser, Paul, Hyslop, Peter St George, Sano, Mary, Bezprozvanny, Ilya, Ehrlich, Michelle E, Holtzman, David M, Gandy, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806870/
https://ncbi.nlm.nih.gov/pubmed/20017949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-51
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