Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

BACKGROUND: Recent reports suggest that latrepirdine (Dimebon™, dimebolin), a retired Russian antihistamine, improves cognitive function in aged rodents and in patients with mild to moderate Alzheimer's disease (AD). However, the mechanism(s) underlying this benefit remain elusive. AD is charac...

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Autors principals: Steele, John W, Kim, Soong H, Cirrito, John R, Verges, Deborah K, Restivo, Jessica L, Westaway, David, Fraser, Paul, Hyslop, Peter St George, Sano, Mary, Bezprozvanny, Ilya, Ehrlich, Michelle E, Holtzman, David M, Gandy, Sam
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806870/
https://ncbi.nlm.nih.gov/pubmed/20017949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-51
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