Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo

BACKGROUND: Recent reports suggest that latrepirdine (Dimebon™, dimebolin), a retired Russian antihistamine, improves cognitive function in aged rodents and in patients with mild to moderate Alzheimer's disease (AD). However, the mechanism(s) underlying this benefit remain elusive. AD is charac...

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Bibliografische gegevens
Hoofdauteurs: Steele, John W, Kim, Soong H, Cirrito, John R, Verges, Deborah K, Restivo, Jessica L, Westaway, David, Fraser, Paul, Hyslop, Peter St George, Sano, Mary, Bezprozvanny, Ilya, Ehrlich, Michelle E, Holtzman, David M, Gandy, Sam
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806870/
https://ncbi.nlm.nih.gov/pubmed/20017949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-51
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