Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

Most familial early-onset Alzheimer’s disease cases are caused by mutations in the presenilin 1 (PS1) gene. Subcellular localization of the endogenous PS1 is essential for understanding its function, interactions with proteins, and role in Alzheimer’s disease. Although numerous studies revealed pred...

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Detalhes bibliográficos
Principais autores: Schwarzman, Alexander L., Singh, Nandita, Tsiper, Maria, Gregori, Luisa, Dranovsky, Alex, Vitek, Michael P., Glabe, Charles G., St. George-Hyslop, Peter H., Goldgaber, Dmitry
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22165/
https://ncbi.nlm.nih.gov/pubmed/10393925
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