The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

BACKGROUND: The accumulation of amyloid beta (Aβ) oligomers or fibrils is thought to be one of the main causes of synaptic and neuron loss, believed to underlie cognitive dysfunction in Alzheimer’s disease (AD). Neuron loss has rarely been documented in amyloid precursor protein (APP) transgenic mou...

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Detalhes bibliográficos
Main Authors: Brautigam, Hannah, Steele, John W, Westaway, David, Fraser, Paul E, George-Hyslop, Peter H St, Gandy, Sam, Hof, Patrick R, Dickstein, Dara L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551697/
https://ncbi.nlm.nih.gov/pubmed/23173713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-58
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