High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity

by Garufi, Alessia, D’Orazi, Gabriella
Published 2014

Reactivation of mutant p53 by capsaicin, the major constituent of peppers

by Garufi, Alessia, Pistritto, Giuseppa, Cirone, Mara, D’Orazi, Gabriella
Published in J Exp Clin Cancer Res (2016)

HIPK2 role in the tumor–host interaction: Impact on fibroblasts transdifferentiation CAF‐like

by Garufi, Alessia, Traversi, Gianandrea, Cirone, Mara, D'Orazi, Gabriella
Published in IUBMB Life (2019)

Zn(II)-curc targets p53 in thyroid cancer cells

by GARUFI, ALESSIA, D'ORAZI, VALERIO, CRISPINI, ALESSANDRA, D'ORAZI, GABRIELLA
Published in Int J Oncol (2015)

Gentian violet induces wtp53 transactivation in cancer cells

by GARUFI, ALESSIA, D’ORAZI, VALERIO, ARBISER, JACK L., D’ORAZI, GABRIELLA
Published 2014

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

by Pistritto, Giuseppa, Trisciuoglio, Daniela, Ceci, Claudia, Garufi, Alessia, D'Orazi, Gabriella
Published in Aging (Albany NY) (2016)

p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions

by Garufi, Alessia, Pistritto, Giuseppa, Baldari, Silvia, Toietta, Gabriele, Cirone, Mara, D’Orazi, Gabriella
Published in J Exp Clin Cancer Res (2017)

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells

by Cirone, Mara, Garufi, Alessia, Di Renzo, Livia, Granato, Marisa, Faggioni, Alberto, D’Orazi, Gabriella
Published 2013

Hyperglycemia triggers HIPK2 protein degradation

by Baldari, Silvia, Garufi, Alessia, Granato, Marisa, Cuomo, Laura, Pistritto, Giuseppa, Cirone, Mara, D'Orazi, Gabriella
Published in Oncotarget (2016)

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

by Cirone, Mara, Gilardini Montani, Maria Saveria, Granato, Marisa, Garufi, Alessia, Faggioni, Alberto, D’Orazi, Gabriella
Published in J Exp Clin Cancer Res (2019)

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation

by Garufi, Alessia, Federici, Giulia, Gilardini Montani, Maria Saveria, Crispini, Alessandra, Cirone, Mara, D’Orazi, Gabriella
Published in Biomolecules (2020)

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulatin...

by Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Garufi, Alessia, D’Orazi, Gabriella, Cirone, Mara
Published in Biomolecules (2020)

p62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex

by Garufi, Alessia, Giorno, Eugenia, Gilardini Montani, Maria Saveria, Pistritto, Giuseppa, Crispini, Alessandra, Cirone, Mara, D’Orazi, Gabriella
Published in Biomolecules (2021)

Targeting COX-2/PGE(2) Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

by Garufi, Alessia, Pistritto, Giuseppa, Ceci, Claudia, Di Renzo, Livia, Santarelli, Roberta, Faggioni, Alberto, Cirone, Mara, D’Orazi, Gabriella
Published 2012

The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

by Garufi, Alessia, Ubertini, Valentina, Mancini, Francesca, D’Orazi, Valerio, Baldari, Silvia, Moretti, Fabiola, Bossi, Gianluca, D’Orazi, Gabriella
Published in J Exp Clin Cancer Res (2015)

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response

by Garufi, Alessia, Traversi, Gianandrea, Gilardini Montani, Maria Saveria, D’Orazi, Valerio, Pistritto, Giuseppa, Cirone, Mara, D’Orazi, Gabriella
Published in Oncotarget (2019)

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

by Garufi, Alessia, Trisciuoglio, Daniela, Porru, Manuela, Leonetti, Carlo, Stoppacciaro, Antonella, D’Orazi, Valerio, Avantaggiati, Maria Laura, Crispini, Alessandra, Pucci, Daniela, D’Orazi, Gabriella
Published 2013

JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells

by Granato, Marisa, Santarelli, Roberta, Lotti, Lavinia V., Di Renzo, Livia, Gonnella, Roberta, Garufi, Alessia, Trivedi, Pankaj, Frati, Luigi, D’Orazi, Gabriella, Faggioni, Alberto, Cirone, Mara
Published 2013

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

by Garufi, Alessia, Baldari, Silvia, Pettinari, Riccardo, Gilardini Montani, Maria Saveria, D’Orazi, Valerio, Pistritto, Giuseppa, Crispini, Alessandra, Giorno, Eugenia, Toietta, Gabriele, Marchetti, Fabio, Cirone, Mara, D’Orazi, Gabriella
Published in J Exp Clin Cancer Res (2020)