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Reactivation of mutant p53 by capsaicin, the major constituent of peppers

BACKGROUND: Mutations in the p53 oncosuppressor gene are highly frequent in human cancers. These alterations are mainly point mutations in the DNA binding domain of p53 and disable p53 from transactivating target genes devoted to anticancer activity. Mutant p53 proteins are usually more stable than...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Garufi, Alessia, Pistritto, Giuseppa, Cirone, Mara, D’Orazi, Gabriella
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012067/
https://ncbi.nlm.nih.gov/pubmed/27599722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-016-0417-9
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