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High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity
BACKGROUND: In response to diverse genotoxic stimuli p53 is activated as transcription factor to exert its tumor-suppressor function. P53 activation requires protein stabilization, nuclear localization and posttranslational modifications in key residues that may influence p53 selection of target gen...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BioMed Central
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4181716/ https://ncbi.nlm.nih.gov/pubmed/25260780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0079-4 |
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