The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

BACKGROUND: Activation of wild-type p53 in response to genotoxic stress occurs through different mechanisms including protein conformation, posttranslational modifications, and nuclear localization, leading to DNA binding to sequence-specific promoters. Zinc ion plays a crucial role in stabilizing p...

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Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Garufi, Alessia, Ubertini, Valentina, Mancini, Francesca, D’Orazi, Valerio, Baldari, Silvia, Moretti, Fabiola, Bossi, Gianluca, D’Orazi, Gabriella
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546314/
https://ncbi.nlm.nih.gov/pubmed/26297485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0206-x
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