A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

BACKGROUND: Mutations of the p53 oncosuppressor gene are amongst the most frequent aberration seen in human cancer. Some mutant (mt) p53 proteins are prone to loss of Zn(II) ion that is bound to the wild-type (wt) core, promoting protein aggregation and therefore unfolding. Misfolded p53 protein con...

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Autori principali: Garufi, Alessia, Trisciuoglio, Daniela, Porru, Manuela, Leonetti, Carlo, Stoppacciaro, Antonella, D’Orazi, Valerio, Avantaggiati, Maria Laura, Crispini, Alessandra, Pucci, Daniela, D’Orazi, Gabriella
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851540/
https://ncbi.nlm.nih.gov/pubmed/24220325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-32-72
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