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Degradation of mutant p53H175 protein by Zn(II) through autophagy

TP53, one of the most important oncosuppressors, is frequently mutated in cancer. Several p53 mutant proteins escape proteolytic degradation and are highly expressed in an aberrant conformation often acquiring pro-oncogenic activities that promote tumor progression and resistance to therapy. Therefo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Garufi, A, Pucci, D, D'Orazi, V, Cirone, M, Bossi, G, Avantaggiati, M L, D'Orazi, G
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044866/
https://ncbi.nlm.nih.gov/pubmed/24874727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.217
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