Epitope-based vaccines: SARS – a model

Por Freund, Natalia Tarnovitski, Sui, Jianhua, Marasco, Wayne A, Gershoni, Jonathan M
Publicado em 2006

Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

Por Wang, Haoqing, Gristick, Harry B, Scharf, Louise, West, Anthony P, Galimidi, Rachel P, Seaman, Michael S, Freund, Natalia T, Nussenzweig, Michel C, Bjorkman, Pamela J
Publicado no eLife (2017)

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Por Barnes, Christopher O., Gristick, Harry B., Freund, Natalia T., Escolano, Amelia, Lyubimov, Artem Y., Hartweger, Harald, West, Anthony P., Cohen, Aina E., Nussenzweig, Michel C., Bjorkman, Pamela J.
Publicado no Nat Commun (2018)

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

Por McGuire, Andrew T., Gray, Matthew D., Dosenovic, Pia, Gitlin, Alexander D., Freund, Natalia T., Petersen, John, Correnti, Colin, Johnsen, William, Kegel, Robert, Stuart, Andrew B., Glenn, Jolene, Seaman, Michael S., Schief, William R., Strong, Roland K., Nussenzweig, Michel C., Stamatatos, Leonidas
Publicado no Nat Commun (2016)

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

Por Freund, Natalia T., Horwitz, Joshua A., Nogueira, Lilian, Sievers, Stuart A., Scharf, Louise, Scheid, Johannes F., Gazumyan, Anna, Liu, Cassie, Velinzon, Klara, Goldenthal, Ariel, Sanders, Rogier W., Moore, John P., Bjorkman, Pamela J., Seaman, Michael S., Walker, Bruce D., Klein, Florian, Nussenzweig, Michel C.
Publicado no PLoS Pathog (2015)

Sequential Immunization Elicits Broadly Neutralizing anti-HIV-1 Antibodies in Ig Knock-in Mice

Por Escolano, Amelia, Steichen, Jon M., Dosenovic, Pia, Kulp, Daniel W., Golijanin, Jovana, Sok, Devin, Freund, Natalia T., Gitlin, Alexander D., Oliveira, Thiago, Araki, Tatsuya, Lowe, Sarina, Chen, Spencer T., Heinemann, Jennifer, Yao, Kai-Hui, Georgeson, Erik, Saye-Francisco, Karen L., Gazumyan, Anna, Adachi, Yumiko, Kubitz, Michael, Burton, Dennis R., Schief, William R., Nussenzweig, Michel C.
Publicado no Cell (2016)

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knock-In Mice

Por Dosenovic, Pia, von Boehmer, Lotta, Escolano, Amelia, Jardine, Joseph, Freund, Natalia T., Gitlin, Alexander D., McGuire, Andrew T., Kulp, Daniel W., Oliveira, Thiago, Scharf, Louise, Pietzsch, John, Gray, Matthew D., Cupo, Albert, van Gils, Marit J., Yao, Kai-Hui, Liu, Cassie, Gazumyan, Anna, Seaman, Michael S., Björkman, Pamela J., Sanders, Rogier W., Moore, John P., Stamatatos, Leonidas, Schief, William R., Nussenzweig, Michel C.
Publicado no Cell (2015)

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Por Freund, Natalia T., Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A., Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A., Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C., Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B., van Gils, Marit J., Sanders, Rogier W., Wang, Lai-Xi, Seaman, Michael S., Burton, Dennis R., Gazumyan, Anna, Walker, Bruce D., West, Anthony P., Bjorkman, Pamela J., Nussenzweig, Michel C.
Publicado no Sci Transl Med (2017)

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

Por Steichen, Jon M., Kulp, Daniel W., Tokatlian, Talar, Escolano, Amelia, Dosenovic, Pia, Stanfield, Robyn L., McCoy, Laura E., Ozorowski, Gabriel, Hu, Xiaozhen, Kalyuzhniy, Oleksandr, Briney, Bryan, Schiffner, Torben, Garces, Fernando, Freund, Natalia T., Gitlin, Alexander D., Menis, Sergey, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Jones, Meaghan, Mutafyan, Andrew A., Yun, Dong Soo, Mayer, Christian T., Ward, Andrew B., Burton, Dennis R., Wilson, Ian A., Irvine, Darrell J., Nussenzweig, Michel C., Schief, William R.
Publicado no Immunity (2016)

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

Por Medina-Ramírez, Max, Garces, Fernando, Escolano, Amelia, Skog, Patrick, de Taeye, Steven W., Del Moral-Sanchez, Ivan, McGuire, Andrew T., Yasmeen, Anila, Behrens, Anna-Janina, Ozorowski, Gabriel, van den Kerkhof, Tom L.G.M., Freund, Natalia T., Dosenovic, Pia, Hua, Yuanzi, Gitlin, Alexander D., Cupo, Albert, van der Woude, Patricia, Golabek, Michael, Sliepen, Kwinten, Blane, Tanya, Kootstra, Neeltje, van Breemen, Mariëlle J., Pritchard, Laura K., Stanfield, Robyn L., Crispin, Max, Ward, Andrew B., Stamatatos, Leonidas, Klasse, Per Johan, Moore, John P., Nemazee, David, Nussenzweig, Michel C., Wilson, Ian A., Sanders, Rogier W.
Publicado no J Exp Med (2017)