Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies

The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediate membrane fusion. The prefusion Env trimer is stabilized by V1V2 loops that interact at the trimer apex. Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Wang, Haoqing, Gristick, Harry B, Scharf, Louise, West, Anthony P, Galimidi, Rachel P, Seaman, Michael S, Freund, Natalia T, Nussenzweig, Michel C, Bjorkman, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biophysics and Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472438/
https://ncbi.nlm.nih.gov/pubmed/28548638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27389
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