Sequential Immunization Elicits Broadly Neutralizing anti-HIV-1 Antibodies in Ig Knock-in Mice

A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be protective, but this has not been achieved. To explore immunization regimens that might elicit bNAbs, we produced and immunized mice expressing the predicted germline of PGT121, a bNAb specific for the V3-lo...

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Publicado no:Cell
Main Authors: Escolano, Amelia, Steichen, Jon M., Dosenovic, Pia, Kulp, Daniel W., Golijanin, Jovana, Sok, Devin, Freund, Natalia T., Gitlin, Alexander D., Oliveira, Thiago, Araki, Tatsuya, Lowe, Sarina, Chen, Spencer T., Heinemann, Jennifer, Yao, Kai-Hui, Georgeson, Erik, Saye-Francisco, Karen L., Gazumyan, Anna, Adachi, Yumiko, Kubitz, Michael, Burton, Dennis R., Schief, William R., Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019122/
https://ncbi.nlm.nih.gov/pubmed/27610569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.07.030
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