Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Some HIV-1–infected patients develop broad and potent HIV-1 neutralizing antibodies (bNAbs) that when passively transferred to mice or macaques can treat or prevent infection. However, bNAbs typically fail to neutralize coexisting autologous viruses due to antibody-mediated selection against sensiti...

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Publicado no:Sci Transl Med
Main Authors: Freund, Natalia T., Wang, Haoqing, Scharf, Louise, Nogueira, Lilian, Horwitz, Joshua A., Bar-On, Yotam, Golijanin, Jovana, Sievers, Stuart A., Sok, Devin, Cai, Hui, Cesar Lorenzi, Julio C., Halper-Stromberg, Ariel, Toth, Ildiko, Piechocka-Trocha, Alicja, Gristick, Harry B., van Gils, Marit J., Sanders, Rogier W., Wang, Lai-Xi, Seaman, Michael S., Burton, Dennis R., Gazumyan, Anna, Walker, Bruce D., West, Anthony P., Bjorkman, Pamela J., Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467220/
https://ncbi.nlm.nih.gov/pubmed/28100831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal2144
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