Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an...

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Publicat a:Nat Commun
Autors principals: McGuire, Andrew T., Gray, Matthew D., Dosenovic, Pia, Gitlin, Alexander D., Freund, Natalia T., Petersen, John, Correnti, Colin, Johnsen, William, Kegel, Robert, Stuart, Andrew B., Glenn, Jolene, Seaman, Michael S., Schief, William R., Strong, Roland K., Nussenzweig, Michel C., Stamatatos, Leonidas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770077/
https://ncbi.nlm.nih.gov/pubmed/26907590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10618
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