Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

af Fliegert, Ralf, Riekehr, Winnie M., Guse, Andreas H.
Udgivet i Front Immunol (2020)

Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling

af Ernst, Insa M. A., Fliegert, Ralf, Guse, Andreas H.
Udgivet 2013

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Degradation by Alkaline Phosphatase

af Schmid, Frederike, Fliegert, Ralf, Westphal, Tim, Bauche, Andreas, Guse, Andreas H.
Udgivet 2012

A Structural Overview of the Ion Channels of the TRPM Family

af Huang, Yihe, Fliegert, Ralf, Guse, Andreas H., Lü, Wei, Du, Juan
Udgivet i Cell Calcium (2019)

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

af Schmeitz, Christine, Hernandez-Vargas, Esteban Abelardo, Fliegert, Ralf, Guse, Andreas H., Meyer-Hermann, Michael
Udgivet 2013

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9

af Gattkowski, Ellen, Rutherford, Trevor J., Möckl, Franziska, Bauche, Andreas, Sander, Simon, Fliegert, Ralf, Tidow, Henning
Udgivet i FEBS J (2021)

Activation of the P2X7 ion channel by soluble and covalently bound ligands

af Schwarz, Nicole, Fliegert, Ralf, Adriouch, Sahil, Seman, Michel, Guse, Andreas H., Haag, Friedrich, Koch-Nolte, Friedrich
Udgivet 2009

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

af Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Guse, Andreas H., Fliegert, Ralf, Potter, Barry V. L.
Udgivet i J Org Chem (2019)

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)

af Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Fliegert, Ralf, Guse, Andreas H., Potter, Barry V. L.
Udgivet i RSC Adv (2020)

Daratumumab and Nanobody-Based Heavy Chain Antibodies Inhibit the ADPR Cyclase but not the NAD(+) Hydrolase Activity of CD38-Expressing Multiple Myeloma Cells

af Baum, Natalie, Fliegert, Ralf, Bauche, Andreas, Hambach, Julia, Menzel, Stephan, Haag, Friedrich, Bannas, Peter, Koch-Nolte, Friedrich
Udgivet i Cancers (Basel) (2020)

Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

af Schwarz, Nicole, Drouot, Laurent, Nicke, Annette, Fliegert, Ralf, Boyer, Olivier, Guse, Andreas H., Haag, Friedrich, Adriouch, Sahil, Koch-Nolte, Friedrich
Udgivet 2012

Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2

af Gattkowski, Ellen, Johnsen, Anke, Bauche, Andreas, Möckl, Franziska, Kulow, Frederike, Garcia Alai, Maria, Rutherford, Trevor J., Fliegert, Ralf, Tidow, Henning
Udgivet i Biochim Biophys Acta Mol Cell Res (2019)

Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

af Moreau, Christelle, Kirchberger, Tanja, Swarbrick, Joanna M., Bartlett, Stephen J., Fliegert, Ralf, Yorgan, Timur, Bauche, Andreas, Harneit, Angelika, Guse, Andreas H., Potter, Barry V. L.
Udgivet 2013

Human Inositol 1,4,5-Trisphosphate 3-Kinase Isoform B (IP3KB) Is a Nucleocytoplasmic Shuttling Protein Specifically Enriched at Cortical Actin Filaments and at Invaginations of the...

af Nalaskowski, Marcus M., Fliegert, Ralf, Ernst, Olga, Brehm, Maria A., Fanick, Werner, Windhorst, Sabine, Lin, Hongying, Giehler, Susanne, Hein, Jamin, Lin, Yuan-Na, Mayr, Georg W.
Udgivet 2011

Inositol 1,4,5-Trisphosphate 3-Kinase-A Is a New Cell Motility-promoting Protein That Increases the Metastatic Potential of Tumor Cells by Two Functional Activities

af Windhorst, Sabine, Fliegert, Ralf, Blechner, Christine, Möllmann, Katharina, Hosseini, Zara, Günther, Thomas, Eiben, Maike, Chang, Lydia, Lin, Hong-Ying, Fanick, Werner, Schumacher, Udo, Brandt, Burkhard, Mayr, Georg W.
Udgivet 2010

8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist

af Kirchberger, Tanja, Moreau, Christelle, Wagner, Gerd K., Fliegert, Ralf, Siebrands, Cornelia C., Nebel, Merle, Schmid, Frederike, Harneit, Angelika, Odoardi, Francesca, Flügel, Alexander, Potter, Barry V. L., Guse, Andreas H.
Udgivet 2009

P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP

af Johnsen, Bjarne, Kaschubowski, Klaus Eric, Nader, Sorush, Schneider, Enja, Nicola, Jan-Andrei, Fliegert, Ralf, Wolf, Insa M. A., Guse, Andreas H., Nikolaev, Viacheslav O., Koch-Nolte, Friedrich, Haag, Friedrich
Udgivet i Purinergic Signal (2019)

Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

af Fliegert, Ralf, Watt, Joanna M., Schöbel, Anja, Rozewitz, Monika D., Moreau, Christelle, Kirchberger, Tanja, Thomas, Mark P., Sick, Wiebke, Araujo, Andrea C., Harneit, Angelika, Potter, Barry V.L., Guse, Andreas H.
Udgivet i Biochem J (2017)

2′-Deoxyadenosine 5′-diphosphoribose is an endogenous TRPM2 superagonist

af Fliegert, Ralf, Bauche, Andreas, Wolf Pérez, Adriana-Michelle, Watt, Joanna M., Rozewitz, Monika D., Winzer, Riekje, Janus, Mareike, Gu, Feng, Rosche, Annette, Harneit, Angelika, Flato, Marianne, Moreau, Christelle, Kirchberger, Tanja, Wolters, Valerie, Potter, Barry V.L., Guse, Andreas H.
Udgivet i Nat Chem Biol (2017)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

af Nebel, Merle, Schwoerer, Alexander P., Warszta, Dominik, Siebrands, Cornelia C., Limbrock, Ann-Christin, Swarbrick, Joanna M., Fliegert, Ralf, Weber, Karin, Bruhn, Sören, Hohenegger, Martin, Geisler, Anne, Herich, Lena, Schlegel, Susan, Carrier, Lucie, Eschenhagen, Thomas, Potter, Barry V. L., Ehmke, Heimo, Guse, Andreas H.
Udgivet 2013