Activation of 5‐HT(2A) receptors by TCB‐2 induces recurrent oscillatory burst discharge in layer 5 pyramidal neurons of the mPFC in vitro

Por Spindle, Michael S., Thomas, Mark P.
Publicado em 2014

Crystal structures of 11β-hydroxysteroid dehydrogenase type 1 and their use in drug discovery

Por Thomas, Mark P, Potter, Barry VL
Publicado em 2011

The structural biology of oestrogen metabolism

Por Thomas, Mark P., Potter, Barry V.L.
Publicado em 2013

The enzymes of human diphosphoinositol polyphosphate metabolism

Por Thomas, Mark P, Potter, Barry V L
Publicado em 2014

Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s Health

Por Thomas, Mark P., Potter, Barry V. L.
Publicado no J Med Chem (2015)

The “Other” Inositols and Their Phosphates: Synthesis, Biology and Medicine (with Recent Advances in myo-Inositol Chemistry)

Por Thomas, Mark P, Mills, Stephen J, Potter, Barry V L
Publicado no Angew Chem Int Ed Engl (2015)

‘Click cyclic ADP-ribose’: a neutral second messenger mimic

Por Swarbrick, Joanna M., Graeff, Richard, Garnham, Clive, Thomas, Mark P., Galione, Antony, Potter, Barry V. L.
Publicado em 2014

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38

Por Swarbrick, Joanna M., Graeff, Richard, Zhang, Hongmin, Thomas, Mark P., Hao, Quan, Potter, Barry V. L.
Publicado em 2014

Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells

Por Moreau, Christelle, Kirchberger, Tanja, Zhang, Bo, Thomas, Mark P., Weber, Karin, Guse, Andreas H., Potter, Barry V. L.
Publicado em 2012

Synthesis and Structure–Activity Relationship Studies of Derivatives of the Dual Aromatase–Sulfatase Inhibitor 4-{[(4-Cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfama...

Por Woo, L W Lawrence, Wood, Paul M, Bubert, Christian, Thomas, Mark P, Purohit, Atul, Potter, Barry V L
Publicado em 2013

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

Por Su, Xiangdong, Vicker, Nigel, Thomas, Mark P, Pradaux-Caggiano, Fabienne, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado em 2011

Aromatase and Dual Aromatase-Steroid Sulfatase Inhibitors from the Letrozole and Vorozole Templates

Por Wood, Paul M, Woo, L W Lawrence, Thomas, Mark P, Mahon, Mary F, Purohit, Atul, Potter, Barry V L
Publicado em 2011

Adamantyl Ethanone Pyridyl Derivatives: Potent and Selective Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1

Por Su, Xiangdong, Pradaux-Caggiano, Fabienne, Vicker, Nigel, Thomas, Mark P, Halem, Heather, Culler, Michael D, Potter, Barry V L
Publicado em 2011

Contribution of Phosphates and Adenine to the Potency of Adenophostins at the IP(3) Receptor: Synthesis of All Possible Bisphosphates of Adenophostin A

Por Sureshan, Kana M., Riley, Andrew M., Thomas, Mark P., Tovey, Stephen C., Taylor, Colin W., Potter, Barry V. L.
Publicado em 2012

Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors

Por Su, Xiangdong, Halem, Heather A., Thomas, Mark P., Moutrille, Cecile, Culler, Michael D., Vicker, Nigel, Potter, Barry V.L.
Publicado em 2012

Regioselective Opening of myo-Inositol Orthoesters: Mechanism and Synthetic Utility

Por Godage, Himali Y., Riley, Andrew M., Woodman, Timothy J., Thomas, Mark P., Mahon, Mary F., Potter, Barry V. L.
Publicado em 2013

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors

Por Leese, Mathew P., Jourdan, Fabrice, Dohle, Wolfgang, Kimberley, Meriel R., Thomas, Mark P., Bai, Ruoli, Hamel, Ernest, Ferrandis, Eric, Potter, Barry V. L.
Publicado em 2011

Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

Por Woo, L W Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P, Sutcliffe, Oliver B, Malini, Bindu, Mahon, Mary F, Purohit, Atul, Potter, Barry V L
Publicado em 2011

A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

Por Mills, Stephen J., Persson, Camilla, Cozier, Gyles, Thomas, Mark P., Trésaugues, Lionel, Erneux, Christophe, Riley, Andrew M., Nordlund, Pär, Potter, Barry V. L.
Publicado em 2012

The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression

Por Stengel, Chloe, Newman, Simon P., Leese, Mathew P., Thomas, Mark P., Potter, Barry V.L., Reed, Michael J., Purohit, Atul, Foster, Paul A.
Publicado no Anticancer Res (2015)