A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery

[Image: see text] Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidyli...

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Detalhes bibliográficos
Main Authors: Mills, Stephen J., Persson, Camilla, Cozier, Gyles, Thomas, Mark P., Trésaugues, Lionel, Erneux, Christophe, Riley, Andrew M., Nordlund, Pär, Potter, Barry V. L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355655/
https://ncbi.nlm.nih.gov/pubmed/22330088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200494d
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