Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase INPP5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family

[Image: see text] The inositol polyphosphate 5-phosphatase INPP5B hydrolyzes the 5-phosphate group from water- and lipid-soluble signaling messengers. Two synthetic benzene and biphenyl polyphosphates (BzP/BiPhPs), simplified surrogates of inositol phosphates and phospholipid headgroups, were identi...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Mills, Stephen J., Silvander, Camilla, Cozier, Gyles, Trésaugues, Lionel, Nordlund, Pär, Potter, Barry V. L.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785718/
https://ncbi.nlm.nih.gov/pubmed/26854536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00838
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