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A Synthetic Polyphosphoinositide Headgroup Surrogate in Complex with SHIP2 Provides a Rationale for Drug Discovery
[Image: see text] Phosphoinositides regulate many cellular processes, and cellular levels are controlled by kinases and phosphatases. SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidyli...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2012
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3355655/ https://ncbi.nlm.nih.gov/pubmed/22330088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200494d |
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