Structure–Activity Relationship for the First-in-Class Clinical Steroid Sulfatase Inhibitor Irosustat (STX64, BN83495)

Structure–activity relationship studies were conducted on Irosustat (STX64, BN83495), the first steroid sulfatase (STS) inhibitor to enter diverse clinical trials for patients with advanced hormone-dependent cancer. The size of its aliphatic ring was expanded; its sulfamate group was N,N-dimethylate...

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Detalhes bibliográficos
Main Authors: Woo, L W Lawrence, Ganeshapillai, Dharshini, Thomas, Mark P, Sutcliffe, Oliver B, Malini, Bindu, Mahon, Mary F, Purohit, Atul, Potter, Barry V L
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262147/
https://ncbi.nlm.nih.gov/pubmed/21990014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201100288
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