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C-3- and C-4-Substituted Bicyclic Coumarin Sulfamates as Potent Steroid Sulfatase Inhibitors
[Image: see text] Synthetic routes to potent bicyclic nonsteroidal sulfamate-based active-site-directed inhibitors of the enzyme steroid sulfatase (STS), an emerging target in the treatment of postmenopausal hormone-dependent diseases, including breast cancer, are described. Sulfamate analogs 9–27 a...
Shranjeno v:
| izdano v: | ACS Omega |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2018
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6173509/ https://ncbi.nlm.nih.gov/pubmed/30320251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b01383 |
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