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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

TRPM2 is a non-selective, Ca(2+)-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR). Until recent cryo-EM structures have exhibited an additional nucleotide binding site in the N-t...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Immunol
Egile Nagusiak: Fliegert, Ralf, Riekehr, Winnie M., Guse, Andreas H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438885/
https://ncbi.nlm.nih.gov/pubmed/32903769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02018
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