Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes

TRPM2 (transient receptor potential melastatin 2) is a Ca(2+)-permeable cation channel gated by ADPR (ADP-ribose) from the cytosolic side. To test whether endogenous concentrations of intracellular ADPR are sufficient for TRPM2 gating in neutrophil granulocytes, we devised an HPLC method to determin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Heiner, Inka, Eisfeld, Jörg, Warnstedt, Maike, Radukina, Natalia, Jüngling, Eberhard, Lückhoff, Andreas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Portland Press Ltd. 2006
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550310/
https://ncbi.nlm.nih.gov/pubmed/16719842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060183
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