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Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone

A decisive element in the human cation channel TRPM2 is a region in its cytosolic C-terminus named NUDT9H because of its homology to the NUDT9 enzyme, a pyrophosphatase degrading ADP-ribose (ADPR). In hTRPM2, however, the NUDT9H domain has lost its enzymatic activity but serves as a binding domain f...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Kühn, Frank, Kühn, Cornelia, Lückhoff, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5671594/
https://ncbi.nlm.nih.gov/pubmed/29163217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00879
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