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Functional Characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells

The human non-selective cation channel TRPM2 represents a mediator of apoptosis triggered by oxidative stress. The principal agonist ADP-ribose binds to the cytosolic domain of TRPM2, which is homologous to the human ADP-ribose pyrophosphatase NUDT9. To further elucidate the structure-function relat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kühn, Frank J. P., Kühn, Cornelia, Lückhoff, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306143/
https://ncbi.nlm.nih.gov/pubmed/25620041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08032
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