Endogenous ADP-ribose enables calcium-regulated cation currents through TRPM2 channels in neutrophil granulocytes

TRPM2 (transient receptor potential melastatin 2) is a Ca(2+)-permeable cation channel gated by ADPR (ADP-ribose) from the cytosolic side. To test whether endogenous concentrations of intracellular ADPR are sufficient for TRPM2 gating in neutrophil granulocytes, we devised an HPLC method to determin...

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Autori principali: Heiner, Inka, Eisfeld, Jörg, Warnstedt, Maike, Radukina, Natalia, Jüngling, Eberhard, Lückhoff, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550310/
https://ncbi.nlm.nih.gov/pubmed/16719842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060183
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