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Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

[Image: see text] TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to oxidative stress and in inflammation. Its role in autoimmune and neurodegenerative diseases makes it an attractive pharmacological target. Binding...

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Pubblicato in:J Org Chem
Autori principali: Baszczyňski, Ondřej, Watt, Joanna M., Rozewitz, Monika D., Guse, Andreas H., Fliegert, Ralf, Potter, Barry V. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2019
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6528165/
https://ncbi.nlm.nih.gov/pubmed/30978018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b00338
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