Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349

TRPM2 (transient receptor potential channel, subfamily melastatin, member 2) is a Ca(2+)-permeable non-selective cation channel activated by the binding of adenosine 5′-diphosphoribose (ADPR) to its cytoplasmic NUDT9H domain (NUDT9 homology domain). Activation of TRPM2 by ADPR downstream of oxidativ...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Biochem J
Hoofdauteurs: Fliegert, Ralf, Watt, Joanna M., Schöbel, Anja, Rozewitz, Monika D., Moreau, Christelle, Kirchberger, Tanja, Thomas, Mark P., Sick, Wiebke, Araujo, Andrea C., Harneit, Angelika, Potter, Barry V.L., Guse, Andreas H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2017
Onderwerpen:
Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473349/
https://ncbi.nlm.nih.gov/pubmed/28515263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20170091
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items