Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists

[Image: see text] Adenosine 5′-diphosphoribose (ADPR) activates TRPM2, a Ca(2+), Na(+), and K(+) permeable cation channel. Activation is induced by ADPR binding to the cytosolic C-terminal NudT9-homology domain. To generate the first structure–activity relationship, systematically modified ADPR anal...

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Main Authors: Moreau, Christelle, Kirchberger, Tanja, Swarbrick, Joanna M., Bartlett, Stephen J., Fliegert, Ralf, Yorgan, Timur, Bauche, Andreas, Harneit, Angelika, Guse, Andreas H., Potter, Barry V. L.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873810/
https://ncbi.nlm.nih.gov/pubmed/24304219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401497a
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