טוען...
Structure–Activity Relationship of Adenosine 5′-diphosphoribose at the Transient Receptor Potential Melastatin 2 (TRPM2) Channel: Rational Design of Antagonists
[Image: see text] Adenosine 5′-diphosphoribose (ADPR) activates TRPM2, a Ca(2+), Na(+), and K(+) permeable cation channel. Activation is induced by ADPR binding to the cytosolic C-terminal NudT9-homology domain. To generate the first structure–activity relationship, systematically modified ADPR anal...
שמור ב:
| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2013
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873810/ https://ncbi.nlm.nih.gov/pubmed/24304219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401497a |
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