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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?

TRPM2 is a non-selective, Ca(2+)-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR). Until recent cryo-EM structures have exhibited an additional nucleotide binding site in the N-t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fliegert, Ralf, Riekehr, Winnie M., Guse, Andreas H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438885/
https://ncbi.nlm.nih.gov/pubmed/32903769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02018
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