Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardiac myocytes evoked by β-adrenergic stimulation. Infusion of NAADP into intact cardiac myocytes induc...

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Detalhes bibliográficos
Main Authors: Nebel, Merle, Schwoerer, Alexander P., Warszta, Dominik, Siebrands, Cornelia C., Limbrock, Ann-Christin, Swarbrick, Joanna M., Fliegert, Ralf, Weber, Karin, Bruhn, Sören, Hohenegger, Martin, Geisler, Anne, Herich, Lena, Schlegel, Susan, Carrier, Lucie, Eschenhagen, Thomas, Potter, Barry V. L., Ehmke, Heimo, Guse, Andreas H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668757/
https://ncbi.nlm.nih.gov/pubmed/23564460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441246
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