Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

P2X7 is a homotrimeric ion channel with two transmembrane domains and a large extracellular ATP-binding domain. It plays a key role in the response of immune cells to danger signals released from cells at sites of inflammation. Gating of murine P2X7 can be induced by the soluble ligand ATP, as well...

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Bibliografske podrobnosti
Main Authors: Schwarz, Nicole, Drouot, Laurent, Nicke, Annette, Fliegert, Ralf, Boyer, Olivier, Guse, Andreas H., Haag, Friedrich, Adriouch, Sahil, Koch-Nolte, Friedrich
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407210/
https://ncbi.nlm.nih.gov/pubmed/22848454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041269
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