Tuning IL-2 signaling by ADP-ribosylation of CD25

Control of immunologic tolerance and homeostasis rely on Foxp3(+)CD4(+)CD25(+) regulatory T cells (Tregs) that constitutively express the high affinity receptor for Interleukin-2, CD25. Tregs proliferate in response to injections of IL-2/anti-IL-2 antibody complexes or low doses of IL-2. However, li...

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Publicado en:Sci Rep
Main Authors: Teege, Sophie, Hann, Alexander, Miksiewicz, Maria, MacMillan, Cary, Rissiek, Björn, Buck, Friedrich, Menzel, Stephan, Nissen, Marion, Bannas, Peter, Haag, Friedrich, Boyer, Olivier, Seman, Michel, Adriouch, Sahil, Koch-Nolte, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354014/
https://ncbi.nlm.nih.gov/pubmed/25753532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08959
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