Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

P2X7 is a homotrimeric ion channel with two transmembrane domains and a large extracellular ATP-binding domain. It plays a key role in the response of immune cells to danger signals released from cells at sites of inflammation. Gating of murine P2X7 can be induced by the soluble ligand ATP, as well...

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Autores principales: Schwarz, Nicole, Drouot, Laurent, Nicke, Annette, Fliegert, Ralf, Boyer, Olivier, Guse, Andreas H., Haag, Friedrich, Adriouch, Sahil, Koch-Nolte, Friedrich
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407210/
https://ncbi.nlm.nih.gov/pubmed/22848454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041269
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