Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21

Tekijä Fletcher, Adam J., James, Leo C.
Julkaisussa J Virol (2016)

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

Tekijä Mathur, Sunil, Fletcher, Adam J., Branigan, Emma, Hay, Ronald T., Virdee, Satpal
Julkaisussa Cell Chem Biol (2020)

Hare TRIM5α Restricts Divergent Retroviruses and Exhibits Significant Sequence Variation from Closely Related Lagomorpha TRIM5 Genes

Tekijä Fletcher, Adam J., Hué, Stéphane, Schaller, Torsten, Pillay, Deenan, Towers, Greg J.
Julkaistu 2010

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

Tekijä Fletcher, Adam J., Mallery, Donna L., Watkinson, Ruth E., Dickson, Claire F., James, Leo C.
Julkaisussa Proc Natl Acad Sci U S A (2015)

Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling

Tekijä Fletcher, Adam J., Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J., James, Leo C.
Julkaisussa Cell Host Microbe (2018)

Cyclophilin A Levels Dictate Infection Efficiency of Human Immunodeficiency Virus Type 1 Capsid Escape Mutants A92E and G94D

Tekijä Ylinen, Laura M. J., Schaller, Torsten, Price, Amanda, Fletcher, Adam J., Noursadeghi, Mahdad, James, Leo C., Towers, Greg J.
Julkaistu 2009

Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases

Tekijä De Cesare, Virginia, Carbajo Lopez, Daniel, Mabbitt, Peter D., Fletcher, Adam J., Soetens, Mathieu, Antico, Odetta, Wood, Nicola T., Virdee, Satpal
Julkaisussa Proc Natl Acad Sci U S A (2021)

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

Tekijä Fletcher, Adam J, Christensen, Devin E, Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J, Sundquist, Wesley I, Towers, Greg J
Julkaisussa EMBO J (2015)

Structural basis for RING-Cys-Relay E3 Ligase Activity and its Role in Axon Integrity

Tekijä Mabbitt, Peter D., Loreto, Andrea, Déry, Marc-André, Fletcher, Adam J., Stanley, Mathew, Pao, Kuan-Chuan, Wood, Nicola T., Coleman, Michael P., Virdee, Satpal
Julkaisussa Nat Chem Biol (2020)

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Tekijä Price, Amanda J., Fletcher, Adam J., Schaller, Torsten, Elliott, Tom, Lee, KyeongEun, KewalRamani, Vineet N., Chin, Jason W., Towers, Greg J., James, Leo C.
Julkaistu 2012

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Tekijä Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J., Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher, James, Leo C.
Julkaistu 2014

HIV-1 evades innate immune recognition through specific co-factor recruitment

Tekijä Rasaiyaah, Jane, Tan, Choon Ping, Fletcher, Adam J., Price, Amanda J., Blondeau, Caroline, Hilditch, Laura, Jacques, David A, Selwood, David L, James, Leo C, Noursadeghi, Mahdad, Towers, Greg J
Julkaistu 2013

Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases

Tekijä Hudson, Andrew M., Stephenson, Natalie L., Li, Cynthia, Trotter, Eleanor, Fletcher, Adam J., Katona, Gitta, Bieniasz-Krzywiec, Patrycja, Howell, Matthew, Wirth, Chris, Furney, Simon, Miller, Crispin J., Brognard, John
Julkaisussa Sci Signal (2018)

Cellular IP(6) Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP(6) Are Attenuated for Infection and Replication

Tekijä Mallery, Donna L., Faysal, K.M. Rifat, Kleinpeter, Alex, Wilson, Miranda S.C., Vaysburd, Marina, Fletcher, Adam J., Novikova, Mariia, Böcking, Till, Freed, Eric O., Saiardi, Adolfo, James, Leo C.
Julkaisussa Cell Rep (2019)

Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

Tekijä Dickson, Claire, Fletcher, Adam J, Vaysburd, Marina, Yang, Ji-Chun, Mallery, Donna L, Zeng, Jingwei, Johnson, Christopher M, McLaughlin, Stephen H, Skehel, Mark, Maslen, Sarah, Cruickshank, James, Huguenin-Dezot, Nicolas, Chin, Jason W, Neuhaus, David, James, Leo C
Julkaisussa eLife (2018)

EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated degradation

Tekijä Guiliano, David B., Fussell, Helen, Lenart, Izabela, Tsao, Edward, Nesbeth, Darren, Fletcher, Adam J., Campbell, Elaine C., Yousaf, Nasim, Williams, Sarah, Santos, Susana, Cameron, Amy, Towers, Greg J., Kellam, Paul, Hebert, Daniel N., Gould, Keith, Powis, Simon J., Antoniou, Antony N.
Julkaisussa Arthritis Rheumatol (2014)

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

Tekijä Schaller, Torsten, Ocwieja, Karen E., Rasaiyaah, Jane, Price, Amanda J., Brady, Troy L., Roth, Shoshannah L., Hué, Stéphane, Fletcher, Adam J., Lee, KyeongEun, KewalRamani, Vineet N., Noursadeghi, Mahdad, Jenner, Richard G., James, Leo C., Bushman, Frederic D., Towers, Greg J.
Julkaistu 2011