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Structural basis for RING-Cys-Relay E3 Ligase Activity and its Role in Axon Integrity
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to non-lysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism where Ub is relayed from an upstream cysteine to a downstream substrate esterification s...
שמור ב:
| הוצא לאור ב: | Nat Chem Biol |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610530/ https://ncbi.nlm.nih.gov/pubmed/32747811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0598-6 |
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