Structural basis for RING-Cys-Relay E3 Ligase Activity and its Role in Axon Integrity

MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to non-lysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism where Ub is relayed from an upstream cysteine to a downstream substrate esterification s...

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Udgivet i:Nat Chem Biol
Main Authors: Mabbitt, Peter D., Loreto, Andrea, Déry, Marc-André, Fletcher, Adam J., Stanley, Mathew, Pao, Kuan-Chuan, Wood, Nicola T., Coleman, Michael P., Virdee, Satpal
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610530/
https://ncbi.nlm.nih.gov/pubmed/32747811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0598-6
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