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Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation
E3 ligases represent an important class of enzymes, yet there are currently no chemical probes to profile their activity. We develop a new class of activity-based probe by reengineering of a ubiquitin-charged E2 conjugating enzyme and demonstrate their utility by profiling the transthiolation activi...
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| Publicado no: | Nat Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909137/ https://ncbi.nlm.nih.gov/pubmed/26928937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2045 |
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