A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation

Ubiquitin phosphorylation is emerging as an important regulatory layer in the ubiquitin system. This is exemplified by the phosphorylation of ubiquitin on Ser65 by the Parkinson's disease-associated kinase PINK1, which mediates the activation of the E3 ligase Parkin. Additional phosphorylation...

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Detalles Bibliográficos
Publicado en:Chembiochem
Autores principales: Han, Cong, Pao, Kuan-Chuan, Kazlauskaite, Agne, Muqit, Miratul M K, Virdee, Satpal
Formato: Artigo
Lenguaje:Inglês
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581463/
https://ncbi.nlm.nih.gov/pubmed/26010437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500185
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