Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65))—which lies within its ubiquitin-like do...

詳細記述

保存先:
書誌詳細
出版年:EMBO Rep
主要な著者: Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley & Sons, Ltd 2015
主題:
Scientific Reports
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552487/
https://ncbi.nlm.nih.gov/pubmed/26116755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540352
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