Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Mutations in the mitochondrial protein kinase PINK1 are associated with autosomal recessive Parkinson disease (PD). We and other groups have reported that PINK1 activates Parkin E3 ligase activity both directly via phosphorylation of Parkin serine 65 (Ser(65))—which lies within its ubiquitin-like do...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Kazlauskaite, Agne, Martínez-Torres, R Julio, Wilkie, Scott, Kumar, Atul, Peltier, Julien, Gonzalez, Alba, Johnson, Clare, Zhang, Jinwei, Hope, Anthony G, Peggie, Mark, Trost, Matthias, van Aalten, Daan MF, Alessi, Dario R, Prescott, Alan R, Knebel, Axel, Walden, Helen, Muqit, Miratul MK
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552487/
https://ncbi.nlm.nih.gov/pubmed/26116755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540352
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