Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)

We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the Parkin E3 ligase by phosphorylating Ser(65) within its Ubl (ubiquitin-like) domain. Using phosphoproteomic analysis,...

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Detalhes bibliográficos
Main Authors: Kazlauskaite, Agne, Kondapalli, Chandana, Gourlay, Robert, Campbell, David G., Ritorto, Maria Stella, Hofmann, Kay, Alessi, Dario R., Knebel, Axel, Trost, Matthias, Muqit, Miratul M. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2014
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000136/
https://ncbi.nlm.nih.gov/pubmed/24660806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140334
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