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Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)
We have previously reported that the Parkinson's disease-associated kinase PINK1 (PTEN-induced putative kinase 1) is activated by mitochondrial depolarization and stimulates the Parkin E3 ligase by phosphorylating Ser(65) within its Ubl (ubiquitin-like) domain. Using phosphoproteomic analysis,...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Portland Press Ltd.
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4000136/ https://ncbi.nlm.nih.gov/pubmed/24660806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140334 |
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