Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation

E3 ligases represent an important class of enzymes, yet there are currently no chemical probes to profile their activity. We develop a new class of activity-based probe by reengineering of a ubiquitin-charged E2 conjugating enzyme and demonstrate their utility by profiling the transthiolation activi...

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Pubblicato in:Nat Chem Biol
Autori principali: Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T., Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M.K., Virdee, Satpal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909137/
https://ncbi.nlm.nih.gov/pubmed/26928937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2045
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