CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with which to interact with cellular cofactors. He...

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Main Authors: Price, Amanda J., Fletcher, Adam J., Schaller, Torsten, Elliott, Tom, Lee, KyeongEun, KewalRamani, Vineet N., Chin, Jason W., Towers, Greg J., James, Leo C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431306/
https://ncbi.nlm.nih.gov/pubmed/22956906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002896
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