HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC protein Nup358/RanBP2 was identified as an HIV-1 co-factor in previous studies. Here we report that HIV-1 capsid (CA) binds d...

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Autori principali: Schaller, Torsten, Ocwieja, Karen E., Rasaiyaah, Jane, Price, Amanda J., Brady, Troy L., Roth, Shoshannah L., Hué, Stéphane, Fletcher, Adam J., Lee, KyeongEun, KewalRamani, Vineet N., Noursadeghi, Mahdad, Jenner, Richard G., James, Leo C., Bushman, Frederic D., Towers, Greg J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234246/
https://ncbi.nlm.nih.gov/pubmed/22174692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002439
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