HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC protein Nup358/RanBP2 was identified as an HIV-1 co-factor in previous studies. Here we report that HIV-1 capsid (CA) binds d...

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Main Authors: Schaller, Torsten, Ocwieja, Karen E., Rasaiyaah, Jane, Price, Amanda J., Brady, Troy L., Roth, Shoshannah L., Hué, Stéphane, Fletcher, Adam J., Lee, KyeongEun, KewalRamani, Vineet N., Noursadeghi, Mahdad, Jenner, Richard G., James, Leo C., Bushman, Frederic D., Towers, Greg J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2011
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234246/
https://ncbi.nlm.nih.gov/pubmed/22174692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002439
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