Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection

The antiviral factor CPSF6-358 interferes with the nuclear entry of human immunodeficiency virus type 1 (HIV-1). HIV-1 acquires resistance to CPSF6-358 through the N74D mutation of the capsid (CA), which alters its nuclear entry pathway. Here we show that compared to wild-type (WT) HIV-1, N74D HIV-1...

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Detalhes bibliográficos
Main Authors: Ambrose, Zandrea, Lee, KyeongEun, Ndjomou, Jean, Xu, Hongzhan, Oztop, Ilker, Matous, James, Takemura, Taichiro, Unutmaz, Derya, Engelman, Alan, Hughes, Stephen H., KewalRamani, Vineet N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318671/
https://ncbi.nlm.nih.gov/pubmed/22301145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05887-11
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