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Flexible Use of Nuclear Import Pathways by HIV-1

The cellular and viral determinants required for HIV-1 infection of nondividing cells have been a subject of intense scrutiny. Here we identify the 68 kDa subunit of cleavage factor Im, CPSF6, as an inhibitor of HIV-1 infection. When enriched in the cytoplasm by high level expression or mutation, CP...

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Detalhes bibliográficos
Main Authors: Lee, KyeongEun, Ambrose, Zandrea, Martin, Thomas D., Oztop, Ilker, Mulky, Alok, Julias, John G., Vandegraaff, Nick, Baumann, Joerg G., Wang, Rui, Yuen, Wendy, Takemura, Taichiro, Shelton, Kenneth, Taniuchi, Ichiro, Li, Yuan, Sodroski, Joseph, Littman, Dan R., Coffin, John M., Hughes, Stephen H., Unutmaz, Derya, Engelman, Alan, KewalRamani, Vineet N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841689/
https://ncbi.nlm.nih.gov/pubmed/20227665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.02.007
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