Flexible Use of Nuclear Import Pathways by HIV-1

The cellular and viral determinants required for HIV-1 infection of nondividing cells have been a subject of intense scrutiny. Here we identify the 68 kDa subunit of cleavage factor Im, CPSF6, as an inhibitor of HIV-1 infection. When enriched in the cytoplasm by high level expression or mutation, CP...

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Main Authors: Lee, KyeongEun, Ambrose, Zandrea, Martin, Thomas D., Oztop, Ilker, Mulky, Alok, Julias, John G., Vandegraaff, Nick, Baumann, Joerg G., Wang, Rui, Yuen, Wendy, Takemura, Taichiro, Shelton, Kenneth, Taniuchi, Ichiro, Li, Yuan, Sodroski, Joseph, Littman, Dan R., Coffin, John M., Hughes, Stephen H., Unutmaz, Derya, Engelman, Alan, KewalRamani, Vineet N.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841689/
https://ncbi.nlm.nih.gov/pubmed/20227665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.02.007
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