Flexible Use of Nuclear Import Pathways by HIV-1

The cellular and viral determinants required for HIV-1 infection of nondividing cells have been a subject of intense scrutiny. Here we identify the 68 kDa subunit of cleavage factor Im, CPSF6, as an inhibitor of HIV-1 infection. When enriched in the cytoplasm by high level expression or mutation, CP...

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Hlavní autoři: Lee, KyeongEun, Ambrose, Zandrea, Martin, Thomas D., Oztop, Ilker, Mulky, Alok, Julias, John G., Vandegraaff, Nick, Baumann, Joerg G., Wang, Rui, Yuen, Wendy, Takemura, Taichiro, Shelton, Kenneth, Taniuchi, Ichiro, Li, Yuan, Sodroski, Joseph, Littman, Dan R., Coffin, John M., Hughes, Stephen H., Unutmaz, Derya, Engelman, Alan, KewalRamani, Vineet N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841689/
https://ncbi.nlm.nih.gov/pubmed/20227665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2010.02.007
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